| Company Name: |
Zhengzhou Converging Chemical Co. LTD Gold
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| Tel: |
0371-0371-53399770 18037166334 |
| Email: |
2853031800@qq.com |
| Products Intro: |
Product Name:EN523
CAS:2094893-05-5
Purity:95% Package:100mg;250mg;1g;5g;10g;25g;100g
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| Company Name: |
Shanghai Synmedia Chemical Co., Ltd.
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| Tel: |
021-38681880 13817889927 |
| Email: |
sales@synmedia-chem.com |
| Products Intro: |
Product Name:EN523
Purity:95% Package:1G, 5G,10G,50G.
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| | 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Basic information |
| Product Name: | 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- | | Synonyms: | 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-;EN523;inhibit,EN-523,Inhibitor,non-catalytic,EN523,OTUB1 recruiter,EN 523,deubiquitinase,allosteric cysteine C23;4-Acryloyl-1-(5-methyl-2-furyl)piperazin-2-one;1-(5-methylfuran-2-yl)-4-(prop-2-enoyl)piperazin-2-one | | CAS: | 2094893-05-5 | | MF: | C12H14N2O3 | | MW: | 234.25 | | EINECS: | | | Product Categories: | | | Mol File: | 2094893-05-5.mol |  |
| | 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Chemical Properties |
| Boiling point | 529.6±50.0 °C(Predicted) | | density | 1.225±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 250 mg/mL (1067.24 mM; Need ultrasonic) | | pka | -0.21±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Usage And Synthesis |
| Biological Activity | EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1]. | | References | [1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421. |
| | 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Preparation Products And Raw materials |
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