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3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)-

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3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Products Intro: Product Name:PERK-IN-5
CAS:2616821-91-9
Package:25mg;1990USD|50mg;3230USD
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:PERK-IN-5
CAS:2616821-91-9
Package:25mg/RMB 17818;50mg/RMB 26697

3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- manufacturers

  • PERK-IN-5
  • PERK-IN-5 pictures
  • $1990.00 / 25mg
  • 2024-10-28
  • CAS:2616821-91-9
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- Basic information
Product Name:3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)-
Synonyms:3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)-;PERK-IN-5
CAS:2616821-91-9
MF:C25H26F2N4O3
MW:468.5
EINECS:
Product Categories:
Mol File:2616821-91-9.mol
3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- Structure
3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- Chemical Properties
Boiling point 681.5±55.0 °C(Predicted)
density 1.311±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (533.62 mM; Need ultrasonic)
pka11.62±0.46(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- Usage And Synthesis
Biological ActivityPERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model[1]. PERK-IN-5 (compound 28) (10-48 μM) is relatively stable in both human and dog hepatocytes and is characterized with long half-lives[1]. PERK-IN-5 (3-100 mg/kg; p.o.; 0.25-24 hours) has robust pharmacokinetics in CD1 mice, with Cmax of 3353 ng/mL, AUC0-last of 5153 h*ng/mL, and bioavailability of 70%[1].PERK-IN-5 (3 or 10 mg/kg; p.o.; twice daily, for 28 days) has statistically significant tumor growth inhibition[1].
References[1]. Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058.
3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- Preparation Products And Raw materials
Tag:3-Pyridinecarboxamide, 2-amino-5-[4-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)-(2616821-91-9) Related Product Information