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2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)

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2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:LEI 101 hydrochloride
CAS:2250025-91-1
Purity:>=98%(HPLC) Package:$276.9/10mg;Bulk package Remarks:98%(HPLC)
Company Name: Hefei fuya biotechnology co. LTD  
Tel: 18096409024
Email: sales02@foreversyn.com
Products Intro: Product Name:2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)
CAS:2250025-91-1
Purity:95% HPLC Package:1G;100G
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:LEI 101 hydrochloride
CAS:2250025-91-1
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:LEI 101 hydrochloride
CAS:2250025-91-1
Purity:详情请点击官网 Package:1 mg
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Basic information
Product Name:2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)
Synonyms:2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)
CAS:2250025-91-1
MF:C23H26ClFN4O4S
MW:508.99
EINECS:
Product Categories:
Mol File:2250025-91-1.mol
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Structure
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Chemical Properties
solubility DMSO:50.9(Max Conc. mg/mL);100.0(Max Conc. mM)
Safety Information
MSDS Information
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Usage And Synthesis
DescriptionLEI 101 hydrochloride is potent and selective CB2 partial agonist.
in vitroLEI-101 behaved as a partial agonist at CB2 receptors using β-arrestin and GTPγS assays and was ~100-fold selective in CB2 /CB1 receptor-binding assays._x000D_ _x000D_ Reference: Br J Pharmacol. 2016 Feb;173(3):446-58. https://pubmed.ncbi.nlm.nih.gov/21923175/
in vivoSystematic modification of physicochemical properties, such as lipophilicity and basicity, was used to optimize the pharmacokinetic profile and hERG affinity of this novel class of cannabinoid CB2 receptor agonists. This led to the identification of 44 (LEI 101) as a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist (hCB2 pEC(50) = 8.0; hERG pK(i) < 4; F(po) = 100%), which was active in a rat spinal nerve ligation model of neuropathic pain._x000D_ _x000D_ Reference: J Med Chem. 2011 Oct 27;54(20):7350-62. https://pubmed.ncbi.nlm.nih.gov/21923175/
targetLEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC50 of 8 for hCB2, and a pKi of less than 4 for hERG.
storageStore at -20°C
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Preparation Products And Raw materials
Tag:2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)(2250025-91-1) Related Product Information