| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:(S)-CCG-1423
CAS:2319939-24-5
Purity:98% Package:100μg;500μg;1mg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:(S)-CCG-1423
CAS:2319939-24-5
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| | Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Basic information |
| | Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Chemical Properties |
| density | 1.469±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml; Ethanol: 0.25 mg/ml | | pka | 12.58±0.70(Predicted) |
| | Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Usage And Synthesis |
| Description | (S)-CCG-1423 is a stereoisomer of CCG-1423 , a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF).1,2 The S-isomer of CCG-1423 inhibits MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration, more potently than the R-isomer.2 | | References | 1. Evelyn, C.R., Wade, S.M., Wang, Q., et al. CCG-1423: A small-molecule inhibitor of RhoA transcriptional signaling Mol. Cancer Ther. 6(8),2249-2260(2007).
2. Watanabe, B., Minami, S., Ishida, H., et al. Stereospecific inhibitory effects of CCG-1423 on the cellular events mediated by myocardin-related transcription factor A PLoS One 10(8),(2015). |
| | Benzamide, N-[(1S)-2-[(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)- Preparation Products And Raw materials |
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