6-(4-硝基苄硫醇)鸟苷
中文名称 | 6-(4-硝基苄硫醇)鸟苷 |
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中文同义词 | 6-(4-硝基苄硫醇)鸟苷;化合物 T12191 |
英文名称 | NBTGR |
英文同义词 | 6-(4-nitrobenzylthio)guanosine;S-(4-NITROBENZYL)-6-THIOGUANOSINE;S-(P-NITROBENZYL)-6-THIOGUANOSINE;NBTGR;2-AMINO-6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE;S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN;NBTG, NBTGR, 2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine;S-(4-Nitrobenzyl)-6-thioguanosine,99% |
CAS号 | 13153-27-0 |
分子式 | C17H18N6O6S |
分子量 | 434.43 |
EINECS号 | |
相关类别 | |
Mol文件 | 13153-27-0.mol |
结构式 |
6-(4-硝基苄硫醇)鸟苷 性质
熔点 | 203-205 °C |
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沸点 | 858.3±75.0 °C(Predicted) |
密度 | 1.3888 (rough estimate) |
折射率 | 1.7000 (estimate) |
储存条件 | 0-6°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 13.07±0.70(Predicted) |
形态 | 固体 |
颜色 | 米白色至黄色 |
Ki: 70 nM (adenosine uptake)
A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides.
安全信息
安全说明 | 24/25 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-108322 | 6-(4-硝基苄硫醇)鸟苷 NBTGR | 13153-27-0 | 1mg | 772元 |
2024/08/19 | HY-108322 | 6-(4-硝基苄硫醇)鸟苷 NBTGR | 13153-27-0 | 5mg | 1700元 |