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| | ANTI-BAP1 Basic information |
| Product Name: | ANTI-BAP1 | | Synonyms: | ANTI-BAP1;ANTI-BRCA1 ASSOCIATED PROTEIN 1;Monoclonal Anti-BAP1 antibody produced in mouse;Anti-DING;Anti-Ring finger protein 2;Anti-RNF2/DING antibody produced in goat;Monoclonal Anti-MAGI1 antibody produced in mouse;Anti-RNF2 (AB2) antibody produced in rabbit | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-BAP1 Structure]() |
| | ANTI-BAP1 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution |
| | ANTI-BAP1 Usage And Synthesis |
| Uses | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit . | | General Description | RING finger protein 2 (RNF2), also known as RNF1b, consists of 336 amino acids and it belongs to PcG (polycomb-group) protein family. This protein is encoded by the gene mapped on human chromosome 1q25.3. The encoded protein is characterized with a unique C3HC4 RING finger motif. | | Biochem/physiol Actions | RING finger protein 2 (RNF2), in association with prohibitin, regulates the activity of E2F transcription factor 1(E2F1) by the direct, prohibitin-mediated pathway and the indirect, p16-mediated pathway. Rnf2 might act as a vital assembly factor in PRC (Polycomb repressive complex), which is required for mammalian development. Decrease in the expression of Rnf2 or ring1b causes gastrulation arrest and cell cycle inhibition. Overexpression of RNF2 results in pathogenesis of urothelial carcinoma of the bladder (UCB). RNF2 interacts with E2 ubiquitin-conjugating enzymes and display E3 ubiquitin ligase activity. RNF2 plays a crucial role in cancer cell survival and proliferation, therefore it can serve as a potential therapeutic target for cancer treatment and prevention. |
| | ANTI-BAP1 Preparation Products And Raw materials |
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