| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Omeprazole sulfone-d3
CAS:2749628-17-7
Purity:95% Package:500μg;1mg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Omeprazole sulfone-d3
CAS:2749628-17-7
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| solubility | Chloroform: slightly soluble; Methanol: slightly, heated | | form | A solid |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Description | Omeprazole sulfone-d3 is intended for use as an internal standard for the quantification of omeprazole sulfone by GC- or LC-MS. Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole magnesium and is found in plasma.1 Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 μM).2 | | References | 1. ?bel?, A., Andersson, T.B., Antonsson, M., et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes Drug Metab. Dispos. 28(8),966-972(2000).
2. Ogilvie, B.W., Yerino, P., Kazmi, F., et al. The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: Implications for coadministration with clopidogrel Drug Metab. Dispos. 39(11),2020-2033(2011). |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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