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Shanghai Huzhen Industrial Co., LTD
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021-60345367 13916550749 |
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sales@shzbio.com |
| Products Intro: |
Product Name:Resistin
Purity:> 99% Package:50ul/RMB 1098;100ul/RMB 1880;200ul/RMB 2900 Remarks:Adipose tissue specific secretory factor; ADSF
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| Product Name: | resistin | | Synonyms: | resistin | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![resistin Structure]() |
| | resistin Chemical Properties |
| | resistin Usage And Synthesis |
| Structure | Resistin has a uniquemotif of 10 cysteines (C-X11-C-X8-
C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C-X3–6-END).Resistin
forms multimeric structures (hexamer and trimer) in circulation
and their assembly is critical for their function.
The crystal structure of resistin reveals an unusual hexameric
structure.Each protomer comprises a
C-terminal disulfide-rich β-sandwich “head” domain
and an N-terminal α-helical “tail” segment. The α-helical
segments associate to form three-stranded coils, and
surface-exposed interchain disulfide linkages mediate
the formation of tail-to-tail hexamers. | | Gene, mRNA, and precursor | Thehumanresistingene,RETN, location 19p13.2, consists
of four exons.Asplicing variant with excluded
Exon 3 exists. Human resistinmRNAhas 327 b that encodes
a signal peptide of 16 aa residues and a mature protein of
92 aa residues. The genes encoding resistin and resistin-like
peptide (Retnl) have been found in mammals, reptiles,
amphibians, and actinistians, but not in birds and fish. | | Biological functions | Resistin knockout mice exhibit low blood glucose
levels after fasting due to reduced hepatic glucose production.
This is partly mediated by the activation of adenosine
monophosphate-activated protein kinase (AMPK)
and the decreased expression of gluconeogenic enzymes
in the liver.Resistin-overexpressing transgenic mice
show hepatic insulin resistance and the promotion of
phosphoenolpyruvate carboxykinase (PEPCK) in the
liver.Resistin-overexpressing rats infected by adenovirus
encoding mouse resistin displayed glucose intolerance
and hyperinsulinemia. | | Clinical implications | Epidemiological studies suggest that resistin is related
to insulin resistance and type 2 diabetes mellitus. Several
single-nucleotide polymorphisms (SNPs) have been demonstrated
to be associated with elevated resistin levels.
Polymorphisms in the RETN promoter region are
associated with resistin levels in obese Japanese individuals
and with an increased risk of coronary disease in a
Chinese population. However, this variant in Europeans
and Caucasians was found not to be correlated with
carotid and coronary atherosclerosis. Increased resistin
levels have been observed in patients with rheumatoid
arthritis and inflammatory bowel disease. | | General Description | Resistin is a cysteine-rich hormone secreted from white
adipocytes. Resistin in mice is involved in insulin resistance
and links obesity to diabetes while human resistin is involved
in inflammation. |
| | resistin Preparation Products And Raw materials |
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