| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:IS-741 potassium
CAS:141284-74-4
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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IS-741 potassium manufacturers
- IS-741 potassium
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- $1520.00 / 25mg
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2024-10-24
- CAS:141284-74-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | IS-741 potassium Basic information |
| Product Name: | IS-741 potassium | | Synonyms: | IS-741 potassium;Cyclohexanecarboxamide, N-[2-[(ethylsulfonyl)amino]-5-(trifluoromethyl)-3-pyridinyl]-, potassium salt (1:1) | | CAS: | 141284-74-4 | | MF: | C15H20F3N3O3S.K | | MW: | 418.5 | | EINECS: | | | Product Categories: | | | Mol File: | 141284-74-4.mol |  |
| | IS-741 potassium Chemical Properties |
| | IS-741 potassium Usage And Synthesis |
| Uses | Fuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site[1][2]. | | References | [1] Noriyuki Kaji, et al. Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa. J Vet Med Sci. 2023 Sep 21. DOI:10.1292/jvms.23-0257
[2] C Bassi. IS-741 (Ishihara Sangyo). Curr Opin Investig Drugs. 2001 Apr;2(4):510-2. PMID:11566008
[3] Shikama H, et al. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol Pharm Bull. 1999 Feb;22(2):127-31. DOI:10.1248/bpb.22.127
[4] Tetsuya Fukunaga, et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9. DOI:10.1007/s00535-002-1081-8 |
| | IS-741 potassium Preparation Products And Raw materials |
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