PBOX 6
中文名称 | PBOX 6 |
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中文同义词 | 化合物 T16436;6-(萘-1-基)苯并[B]吡咯并[1,2-D][1,4]氧氮杂卓-7-基 二甲基氨基甲酸酯 |
英文名称 | PBOX-6 |
英文同义词 | PBOX-6;Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7-yl ester;PBOX-6 >=98% (HPLC);6-(Naphthalen-1-yl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-yl dimethylcarbamate |
CAS号 | 290814-68-5 |
分子式 | C25H20N2O3 |
分子量 | 396.44 |
EINECS号 | |
相关类别 | |
Mol文件 | 290814-68-5.mol |
结构式 | ![]() |
PBOX 6 性质
熔点 | 177-179 °C(Solv: ethanol (64-17-5)) |
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沸点 | 580.6±50.0 °C(Predicted) |
密度 | 1.22±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
酸度系数(pKa) | -1.32±0.70(Predicted) |
颜色 | 白色至米色 |
Apoptosis, Microtubule
PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells. PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-U00446 | PBOX 6 PBOX 6 | 290814-68-5 | 5mg | 1600元 |
2024/04/30 | HY-U00446 | PBOX 6 | 10 mM * 1 mLin DMSO | 1760元 |