| Company Name: |
AntibodySystem
|
| Tel: |
17762345272 18162686757 |
| Email: |
biolab-reagents@atagenix.com |
| Products Intro: |
Product Name:Progranulin
Purity:95% SDS-PAGE Package:1mg;100ug
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| Company Name: |
ACROBiosystems
|
| Tel: |
18514007688 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
| Products Intro: |
Product Name:Progranulin
|
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| | progranulin Basic information |
| Product Name: | progranulin | | Synonyms: | progranulin | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![progranulin Structure]() |
| | progranulin Chemical Properties |
| | progranulin Usage And Synthesis |
| Enzyme inhibitor | This 93-residue, cysteine-rich granulin precursor (MW = 88 kDa; Symbol: PGRN), also called proepithelin and PC cell-derived growth factor, is a pleiotrophic growth factor with important roles in maintaining and regulating the homeostatic dynamics of normal tissue development, proliferation, regeneration, and host-defense. PGRN also has potent antiinflammatory properties, and its deregulation is associated with rheumatoid arthritis and inflammatory bowel disease. Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice. Recombinant PGRN protein strongly inhibits TNF and the expression of interferon-γ-induced chemokines CXCL9 and CXCL10. Moreover, in PGRNnull mice, many chemokines, including CXCL9 and CXCL10, are significantly induced. |
| | progranulin Preparation Products And Raw materials |
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