| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Apo-SAA human
Purity:recombinant, expressed in E. coli, >=98% (SDS-PAGE), >=98% ( Package:50UG Remarks:SRP4324-50UG
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Product Name:Apo-SAA human
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| Company Name: |
Nacalai Tesque, Inc.
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| Tel: |
81 75 251 1723 |
| Email: |
info-tech@nacalai.co.jp |
| Products Intro: |
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| | APO-SERUM AMYLOID A, HUMAN Basic information |
| | APO-SERUM AMYLOID A, HUMAN Chemical Properties |
| storage temp. | -20°C | | form | lyophilized |
| | APO-SERUM AMYLOID A, HUMAN Usage And Synthesis |
| Uses | Apo-serum amyloid A has been used to study its effect on the expression of Visfatin in macrophages. | | General Description | Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. | | Biochem/physiol Actions | Serum amyloid A (SAA) is found normally at concentrations of 0.1μM in blood. However, its concentration increases up to 1000-fold under stress. It has been associated with several chronic inflammatory diseases, such as atherosclerosis. It is found to participate in the inflammatory response by facilitating chemotaxis, migration, and adhesion of inflammatory cells, particularly monocytes/macrophages. SAA is also found to induce the synthesis and secretion of multiple kinds of inflammatory cytokines, such as TNF-α (tumor necrosis factor-α), IL-1β (interleukin-1β), MCP-1 (monocyte chemoattractant protein-1), and Lp-PLA2 (lipoprotein-associated phospholipase A2). |
| | APO-SERUM AMYLOID A, HUMAN Preparation Products And Raw materials |
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