| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-α-Catenin
Purity:whole antiserum Package:0.2mL, 1mL Remarks:C2206
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| | Anti-α-Catenin Basic information |
| Product Name: | Anti-α-Catenin | | Synonyms: | Anti-α-Catenin;Anti-α-Catenin antibody produced in rabbit;Anti-α-Catenin-Biotin antibody produced in rabbit;Anti-CATNB;Anti-CTNB1;Anti-CTNNB1;Anti-phospho-β-catenin (pTyr333) antibody produced in rabbit;Anti-DKFZp686D02253 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Anti-α-Catenin Structure]() |
| | Anti-α-Catenin Chemical Properties |
| | Anti-α-Catenin Usage And Synthesis |
| Uses | Anti-α-Catenin antibody has been used:
- in dot blot immunoassay
- in immunoblotting
- in immunofluorescence
- in western blotting
- in immunoprecipitation
- in immunofluorescence staining
- in coimmunoprecipitation
| | General Description | Catenin are distinct peripheral cytosolic proteins, α, β, and γ -catenin (102 kDa, 94 kDa and 86 kDa, respectively) are found in varying abundance in many developing and adult tissues. Within its conserved regions, α-catenin shows 30% identity to vinculin, a protein found mainly in focal cell-cell and cell substrate adhesions. | | Biochem/physiol Actions | Catenins bind, directly or indirectly, to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Cadherins are transmembrane cell surface glycoprotein molecules that mediate calcium-dependent intercellular interactions and are important for tissue morphogenesis. Catenins link E-cadherin to other integral membrane proteins such as Na+ /K+ -ATPase, or to cytoplasmic proteins such as fodrin, ankyrin, sarcoma (Src) and Yes kinases and are modulated by Wnt-1 protooncogene. They are considered good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. α-Catenin appears to be capable of interacting with N-cadherin and P-cadherin. Absence of α-catenin is found in certain tumor cell lines. Frequent reduction of α-catenin levels in human carcinomas of the esophagus, stomach and colon is also reported. Prostate cancer development appears to be correlated with α-catenin gene deletions. |
| | Anti-α-Catenin Preparation Products And Raw materials |
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