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Anti-FRS2 (SNT-1) antibody produced in rabbit

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Anti-FRS2 (SNT-1) antibody produced in rabbit Suppliers list
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
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Products Intro: Remarks:affinity isolated antibody, buffered aqueous solution
Company Name: SIGMA-RBI  
Tel: 800 736 3690 (Orders)
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Anti-FRS2 (SNT-1) antibody produced in rabbit Chemical Properties
storage temp. -20°C
form buffered aqueous solution
Safety Information
Safety Statements 23-24/25
MSDS Information
Anti-FRS2 (SNT-1) antibody produced in rabbit Usage And Synthesis
General DescriptionFibroblast growth factor receptor substrate 2 (FRS2), also known as suc-1 associated neurotrophic factor target protein (SNT) exist in two structurally similar forms namely, FRS2a (SNT-1) and FRS-2b (SNT-2). FRS2 is characterized with a consensus myristylation sequence, involved in its recruitment to the cell membrane 4 and a putative phosphotyrosine binding (PTB) domain in its amino-terminus.
Biochem/physiol ActionsFibroblast growth factors (FGF) receptor substrate (FRS) functions as a lipid-anchored docking protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. fibroblast growth factor receptor substrate 2 (FRS2) plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor (NGF) with the Ras/ mitogen-activated protein kinases (MAPKs) signaling pathway, thus relaying information from the cell surface to the nucleus. FRS2 proteins are tyrosine phosphorylated in response to activation of the RET receptor, a tyrosine kinase that functions as the signal transducing receptor for the glial cell line-derived neurotrophic factor (GDNF).
Anti-FRS2 (SNT-1) antibody produced in rabbit Preparation Products And Raw materials
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