101387-97-7
中文名称 | 101387-97-7 |
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中文同义词 | 化合物 T19549 |
英文名称 | 5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one |
英文同义词 | 5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one;Ro-18-5362;Indeno[5,6-d]imidazol-6(1H)-one, 5,7-dihydro-2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-5,5,7,7-tetramethyl-;Ro185362,Ro18 5362,Ro-18-5362 |
CAS号 | 101387-97-7 |
分子式 | C22H25N3O2S |
分子量 | 395.52 |
EINECS号 | |
相关类别 | |
Mol文件 | 101387-97-7.mol |
结构式 |
101387-97-7 性质
沸点 | 593.4±60.0 °C(Predicted) |
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密度 | 1.27±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 10.28±0.60(Predicted) |
Marked differences are seen between Ro 18-5364 (sulfoxide) and Ro18-5362 (sulfide) with regard to inhibitory activity. Even at concentrations as high as 0.1 mM Ro18-5362 fails to affect significantly (H + +K + )-ATPase activity and associated proton translocation. The sulfoxide Ro 18-5364, a potential metabolite of the IND Ro18-5362, is a powerful inhibitor of gastric mucosal (H + +K + )-ATPase, decreasing enzymatic activity with an apparent K i of 0.1 μM.