Unii-T4np8G3K6q
| 中文名称 | Unii-T4np8G3K6q |
|---|---|
| 中文同义词 | 巴他布林;化合物BATABULIN |
| 英文名称 | Unii-T4np8G3K6q |
| 英文同义词 | Batabulin;Batabulin [inn];Benzenesulfonamide, 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-;N-(3-Fluoro-4-methoxyphenyl)-2,3,4,5,6-pentafluorobenzenesulfonamide;T 138067;Tl 057;Unii-T4np8G3K6q;2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzenesulfonamide |
| CAS号 | 195533-53-0 |
| 分子式 | C13H7F6NO3S |
| 分子量 | 371.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 195533-53-0.mol |
| 结构式 |  |
Unii-T4np8G3K6q 性质
| 沸点 | 403.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.629±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：100 mg/mL（269.35 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.74±0.10(Predicted) |
| 颜色 | 白色至米白色 |
β-tubulin
Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary.
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis.
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy.
Cell Cycle Analysis
| Cell Line: | MCF7 cells |
| Concentration: | 30 nM, 100 nM and 300 nM |
| Incubation Time: | 24 hours |
| Result: | Showed an arrest at the G2/M cell-cycle boundary. |
Apoptosis Analysis
| Cell Line: | MCF7 cells |
| Concentration: | 30 nM, 100 nM and 300 nM |
| Incubation Time: | 24 hours or 48 hours |
| Result: | 25-30% of cells showed the reduced DNA content characteristic of apoptotic cells. |
Batabulin (T138067; 40 mg/kg; intraperitoneal injection; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors.
| Animal Model: | Male athymic nude mice ( nu/nu ) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells |
| Dosage: | 40 mg/kg |
| Administration: | Intraperitoneal injection; once per week; on days 5, 12, and 19 |
| Result: | Impaired the growth of the drug-sensitive CCRF-CEM tumors. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-13563 | Batabulin | 1 mg | 550元 | |
| 2024/04/30 | HY-13563 | Unii-T4np8G3K6q Batabulin | 195533-53-0 | 5mg | 1500元 |