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| | Nsc66811 Basic information |
| Product Name: | Nsc66811 | | Synonyms: | Nsc66811;2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol;7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol;8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-;NSC 66811; NSC66811; NSC-66811;8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline;7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol;2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol | | CAS: | 6964-62-1 | | MF: | C23H20N2O | | MW: | 340.42 | | EINECS: | | | Product Categories: | | | Mol File: | 6964-62-1.mol |  |
| | Nsc66811 Chemical Properties |
| Melting point | 143.0 to 147.0 °C | | Boiling point | 529.5±45.0 °C(Predicted) | | density | 1.235±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Soluble in DMSO (up to 25 mg/ml). | | form | solid | | pka | 4.42±0.50(Predicted) | | color | White | | λmax | 250nm(EtOH)(lit.) | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | Nsc66811 Usage And Synthesis |
| Description | NSC 66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable. | | Uses | NSC 66811 is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. NSC 66811 activates p53 in colon cancer cells. | | References | 1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759 |
| | Nsc66811 Preparation Products And Raw materials |
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