1140525-25-2
中文名称 | 1140525-25-2 |
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中文同义词 | N2-[2-(2,2-二苯基乙氧基)乙酰基]-L-精氨酸三氟乙酸盐;化合物SB290157 TRIFLUOROACETATE;SB290157 三氟乙酸盐 |
英文名称 | SB 290157 trifluoroacetate salt |
英文同义词 | SB 290157 trifluoroacetate salt;SB290157 (trifluoroacetate);SB 290157 TRIFLUOROACETATE; SB-290157 TRIFLUOROACETATE;SB 290157 - CAS 1140525-25-2 - Calbiochem;(2S)-5-(diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acid;N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine, 2,2,2-trifluor;N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine (trifluoroacetate);SB290157,SB-290157 trifluoroacetate,Inhibitor,inhibit,SB 290157,Complement System,SB-290157,SB290157 trifluoroacetate |
CAS号 | 1140525-25-2 |
分子式 | C24H29F3N4O6 |
分子量 | 526.51 |
EINECS号 | |
相关类别 | 氨基酸 |
Mol文件 | 1140525-25-2.mol |
结构式 | ![]() |
1140525-25-2 性质
熔点 | >43°C (dec.) |
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储存条件 | -20°C |
溶解度 | 可溶于乙醇(轻微,超声),甲醇(轻微),水(轻微) |
形态 | 粉末 |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D +1.5 to +5°, c = 1.0 in DMSO |
稳定性 | 吸湿性 |
Target | Value |
RBL-C3aR
(Cell-free assay) | 200 nM |
SB 290157, functions as a competitive antagonist of 125 I-C3a radioligand binding to rat basophilic leukemia-2H3 cells expressing the human C3aR (RBL-C3aR), with an IC 50 of 200 nM. SB 290157 blocks C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca 2+ mobilization in RBL-C3aR cells and human neutrophils with IC 50 s f 27.7 and 28 nM, respectively. SB 290157 is selective for the C3aR in that it does not antagonize the C5aR or six other chemotactic G protein-coupled receptors. SB 290157 also inhibits C3a-induced Ca 2+ mobilization of RBL-2H3 cells expressing the mouse and guinea pig C3aRs. It potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery.
SB 290157, inhibits neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model and decreases paw edema in a rat adjuvant-induced arthritis model. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30 mg/kg. The C3 level is significantly decreased at 3 h compared with naive mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101502A | SB290157 trifluoroacetate | 1 mg | 272元 | |
2024/04/30 | HY-101502A | 1140525-25-2 SB290157 trifluoroacetate | 1140525-25-2 | 10mM * 1mLin DMSO | 695元 |