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| (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Basic information |
Product Name: | (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride | Synonyms: | (R)-b-Amino-2,4,5-trifluoro-benzenebutanoic acid HCl;Sitagliptin Impurity 17;Sitagliptin Acid Impurity HCl;Sitagliptin-2;Sitagliptin impurity 37/(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid hydrochloride;(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid,hydrochloride;(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride;(3R)-3-amino -4-(2, 4-difluorophenyl)-1-[3-(trifluoromethyl)butyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one | CAS: | 1204818-19-8 | MF: | C10H11ClF3NO2 | MW: | 269.6480496 | EINECS: | | Product Categories: | | Mol File: | 1204818-19-8.mol | |
| (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Chemical Properties |
Melting point | 218-220℃ | storage temp. | Inert atmosphere,Room Temperature | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | color | White to Off-White | Sensitive | Air Sensitive | Stability: | Hygroscopic |
| (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Usage And Synthesis |
Uses | (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is an intermediate in the synthesis of the new antidiabetic drug Sitagliptine (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor. |
| (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Preparation Products And Raw materials |
Raw materials | (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate-->ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate-->Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid-->Sitagliptin Impurity-->2,2-DiMethyl-5-[(2,4,5-trifluorophenyl)acetyl]-1,3-dioxane-4,6-dione-->ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate-->(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid-->(R)-Ethyl 2,4,5-trifluoro-b-homophenylalaninateHCl-->1-Bromo-2,4,5-trifluorobenzene-->2,4,5-Trifluorophenylacetic acid |
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