NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE
中文名称 | NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE |
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中文同义词 | 化合物 T12199L |
英文名称 | NB598 hydrochloride |
英文同义词 | NB 598 hydrochloride;NB-598 (hydrochloride);NB598 hydrochloride;NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE |
CAS号 | 136719-25-0 |
分子式 | C27H32ClNOS2 |
分子量 | 486.13 |
EINECS号 | |
相关类别 | |
Mol文件 | 136719-25-0.mol |
结构式 | ![]() |
NB 598 HYDROCHLORIDE; NB598 HYDROCHLORIDE 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
squalene epoxidase
NB598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 dose-dependently inhibits insulin secretion under both basal (1 mM glucose) and glucose-stimulated (16.7 mM glucose) conditions. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [ 14 C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium.