AA26-9
中文名称 | AA26-9 |
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中文同义词 | AA26-9游离态;化合物AA26-9;吡咯烷-1-基(1H-1,2,3-三唑-1-基)甲酮 |
英文名称 | Methanone, 1-pyrrolidinyl-1H-1,2,3-triazol-1-yl- |
英文同义词 | Methanone, 1-pyrrolidinyl-1H-1,2,3-triazol-1-yl-;Pyrrolidin-1-yl-[1,2,3]triazol-1-yl-methanone;AA26-9;peptidases,thioesterases,AA26-9,Phospholipase,AA269,serine,esterases,AA-26-9,AA26 9,Inhibitor,lipases,amidases,inhibit,cell;AA26-8;Pyrrolidin-1-yl(1H-1,2,3-triazol-1-yl)methanone |
CAS号 | 1312782-34-5 |
分子式 | C7H10N4O |
分子量 | 166.18 |
EINECS号 | |
相关类别 | |
Mol文件 | 1312782-34-5.mol |
结构式 | ![]() |
AA26-9 性质
沸点 | 306.7±25.0 °C(Predicted) |
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密度 | 1.42±0.1 g/cm3(Predicted) |
储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
溶解度 | DMSO:100.0(最大浓度 mg/mL);601.76(最大浓度 mM) |
形态 | 固体 |
酸度系数(pKa) | -0.71±0.70(Predicted) |
颜色 | 白色至米白色 |
AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-18522 | AA26-9 AA26-9 | 1312782-34-5 | 5mg | 900元 |
2024/08/19 | HY-18522 | AA26-9 AA26-9 | 1312782-34-5 | 10mM * 1mLin DMSO | 990元 |