| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:PU 02
CAS:313984-77-9
Purity:97% by HPLC Remarks:PU 02 is a potent and selective 5-HT3 receptor antagonist (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively). It is selective for 5-HT3
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| Company Name: |
HangZhou YuHao Chemical Technology Co., Ltd.
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| Tel: |
0571-82693216 |
| Email: |
info@yuhaochemical.com |
| Products Intro: |
Product Name:6-[(1-Naphthalenylmethyl)thio]-9H-purine
CAS:313984-77-9
Purity:98% Package:1g; 10g; 100g
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| | 6-[(1-NaphthalenylMethyl)thio]-9H-purine Basic information |
| Product Name: | 6-[(1-NaphthalenylMethyl)thio]-9H-purine | | Synonyms: | 6-[(1-NaphthalenylMethyl)thio]-9H-purine;PU 02;6-((Naphthalen-1-ylmethyl)thio)-7H-purine;6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine;PU-02; PU02;9H-Purine, 6-[(1-naphthalenylmethyl)thio]-;5-HT Receptor,cyclin B1,cyclinD1,Inhibitor,Apoptosis,Serotonin Receptor,PU02,PU 02,HepG2,CDK4,5-hydroxytryptamine Receptor,inhibit | | CAS: | 313984-77-9 | | MF: | C16H12N4S | | MW: | 292.36 | | EINECS: | | | Product Categories: | | | Mol File: | 313984-77-9.mol | ![6-[(1-NaphthalenylMethyl)thio]-9H-purine Structure](CAS/20150408/GIF/313984-77-9.gif) |
| | 6-[(1-NaphthalenylMethyl)thio]-9H-purine Chemical Properties |
| storage temp. | 2-8°C | | solubility | Soluble to 100 mM in DMSO | | form | Powder |
| | 6-[(1-NaphthalenylMethyl)thio]-9H-purine Usage And Synthesis |
| Description | PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors. It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis. |
| | 6-[(1-NaphthalenylMethyl)thio]-9H-purine Preparation Products And Raw materials |
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