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| | NIBR189 Basic information |
| Product Name: | NIBR189 | | Synonyms: | NIBR189;(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one;(2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one;2-Propen-1-one, 3-(4-bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-, (2E)-;(2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one;NIBR-189; NIBR 189;CS-1583;Inhibitor,mice,small molecule,NIBR 189,autoimmune diseases,autoimmune,EBI2/GPR183,NIBR189,U937,NIBR-189,G protein,inhibit,migration | | CAS: | 1599432-08-2 | | MF: | C21H21BrN2O3 | | MW: | 429.31 | | EINECS: | | | Product Categories: | api | | Mol File: | 1599432-08-2.mol |  |
| | NIBR189 Chemical Properties |
| Boiling point | 639.7±55.0 °C(Predicted) | | density | 1.403±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | | form | solid | | pka | -0.86±0.70(Predicted) | | color | White to off-white |
| | NIBR189 Usage And Synthesis |
| Uses | (2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one recently known as NIBR 189, is a selective Epstein-barr virus-induced gene 2 (EBI-2) receptor antagonist, resulting in a modulation of immune responses related to auto-immune diseases. | | Biological Activity | nibr189 is a small molecule antagonist of the epstein-barr virus-induced gene 2 (ebi2; gpr183) receptor with ic50 of 16 nm(binding) and 11 nm (functional). | | storage | Store at +4°C |
| | NIBR189 Preparation Products And Raw materials |
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