3-IODOBENZYL-GUANIDINE HEMISULFATE manufacturers
- Iobenguane sulfate
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- $64.00 / 5mg
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2024-11-19
- CAS:87862-25-7
- Min. Order:
- Purity: 99.04%
- Supply Ability: 10g
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| 3-IODOBENZYL-GUANIDINE HEMISULFATE Basic information |
Product Name: | 3-IODOBENZYL-GUANIDINE HEMISULFATE | Synonyms: | M-IBG;MIBG HEMISULFATE SALT;M-IODOBENZYLGUANIDINE HEMISULFATE SALT;M-IODOBENZYLGUANIDINE 1/2H2SO4;Guanidine, [(3-iodophenyl)methyl]-, sulfate (2:1);meta-Iodobenzylguanidine hemisulfate;MIBG hemisulfate;m-iodobenzylguanidine sulfate | CAS: | 87862-25-7 | MF: | C16H22I2N6O4S | MW: | 648.26 | EINECS: | | Product Categories: | | Mol File: | 87862-25-7.mol | |
| 3-IODOBENZYL-GUANIDINE HEMISULFATE Chemical Properties |
storage temp. | 2-8°C | solubility | DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml | form | A crystalline solid | color | White to off-white |
WGK Germany | 3 | HS Code | 2909309090 |
| 3-IODOBENZYL-GUANIDINE HEMISULFATE Usage And Synthesis |
Description | m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity. It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 μg/ml and reduces clonogenic survival of L1210 leukemia cells in a concentration-dependent manner. MIBG increases survival in N1E155 and L1210 mouse xenograft models when administered at doses of 40 and 20 mg/kg, respectively. It selectively accumulates in chromaffin tissues and tumors and formulations containing radiolabeled forms of MIBG have been used as imaging agents in the diagnosis and treatment of neuroendocrine tumors. MIBG also inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes. | Chemical Properties | Colourless to off-white solid | Uses | m-Iodobenzylguanidine Hemisulfate?can be used to demethylate and oxidize membrane-associated DNA. It has also been employed to develop a cell-based high-throughput screening assay to identify anti-hepatitis C virus compounds. | Biochem/physiol Actions | Antitumor agent which inhibits ADP ribosylation. |
| 3-IODOBENZYL-GUANIDINE HEMISULFATE Preparation Products And Raw materials |
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