环(组氨酰-脯氨酰)
中文名称 | 环(组氨酰-脯氨酰) |
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中文同义词 | 环(组氨酰-脯氨酰);(3S,8AS)-六氢-3-(1H-咪唑-4-基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮;化合物CYCLO(HIS-PRO);CYCLO(HIS-PRO) (CYCLO(HISTIDYL-PROLINE));(3S,8AS)-3-[(4-咪唑基)甲基]六氢吡咯并[1,2-A]吡嗪-1,4-二酮;普罗瑞林EP杂质E |
英文名称 | CYCLO(-HIS-PRO) |
英文同义词 | (3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione;Histidylproline diketopiperazine;histidylproline dioxopiperazine;Cyclo-Pro-His-HO;HIS-PRO, CYCLIC;CYCLO(-HIS-PRO);Cyclo(histidyl-proline);CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE |
CAS号 | 53109-32-3 |
分子式 | C11H14N4O2 |
分子量 | 234.25 |
EINECS号 | |
相关类别 | 氨基酸中间体;多肽中间体;标准品 |
Mol文件 | 53109-32-3.mol |
结构式 | ![]() |
环(组氨酰-脯氨酰) 性质
熔点 | 162-164 °C |
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沸点 | 659.3±48.0 °C(Predicted) |
密度 | 1.41±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMF:1mg/mL; DMSO:1mg/mL;乙醇:1mg/mL; PBS(pH 7.2):1 mg/mL |
形态 | 油状物 |
酸度系数(pKa) | 12.73±0.40(Predicted) |
颜色 | 浅黄至黄色 |
NF-κB
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Human Endogenous Metabolite
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cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors.
cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release.
Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway.
Western Blot Analysis
Cell Line: | PC12 cells |
Concentration: | 50 μM |
Incubation Time: | 1, 2, 4, 8, 24, 48 hours |
Result: | Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation. |
Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect.
Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress.
Animal Model: | Sixty two/three month-old male C57BL/6 mice (25-30 g) |
Dosage: | 1.8 mg/ear |
Administration: | Topical application on the right ear; 30 min prior to TPA |
Result: | Reduced TPA-induced ear oedema. |
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101402 | 环(组氨酰-脯氨酰) Cyclo(his-pro) | 53109-32-3 | 1mg | 500元 |
2024/04/30 | HY-101402 | 环(组氨酰-脯氨酰) Cyclo(his-pro) | 53109-32-3 | 5mg | 900元 |