AC-ARG-ARG-TRP-TRP-CYS-ARG- NH2
| 中文名称 | AC-ARG-ARG-TRP-TRP-CYS-ARG- NH2 |
|---|---|
| 中文同义词 | 趋化因子受体 (CXCR) 抑制剂多肽IL-8 INHIBITOR |
| 英文名称 | AC-ARG-ARG-TRP-TRP-CYS-ARG-NH2 |
| 英文同义词 | IL-8 INHIBITOR;AC-ARG-ARG-TRP-TRP-CYS-ARG-NH2;AC-RRWWCR-NH2;IL-8 Inhibitor, Antileukinate;L-Argininamide, N2-acetyl-L-arginyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-cysteinyl- |
| CAS号 | 138559-60-1 |
| 分子式 | C45H66N18O7S |
| 分子量 | 1003.19 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 138559-60-1.mol |
| 结构式 |  |
AC-ARG-ARG-TRP-TRP-CYS-ARG- NH2 性质
| 密度 | 1.52±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -15°C |
| 溶解度 | DMF：1mg/mL； DMSO：5mg/mL； PBS（pH 7.2）：2 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.16±0.10(Predicted) |
Antileukinate 是一种六肽，是有效的 CXC 趋化因子受体 (CXCR) 抑制剂。Antileukinate 能抑制中性粒细胞趋化和活化。Antileukinate 可用于急性炎症和损伤的研究。
Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC
50
of 8.2 μM.
Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin.
Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury.
Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil.
| Animal Model: | Swiss mice (20-25g) |
| Dosage: | 52.63 mg/kg |
| Administration: | Subcutaneous injection |
| Result: | Reduced pancreatic edema induced by Caerulein (50 μg/kg). |