| Company Name: |
AdooQ BioScience, LLC
|
| Tel: |
+1 (866) 930-6790 |
| Email: |
info@adooq.com |
| Products Intro: |
Product Name:CA-224
CAS:883561-04-4
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
|
| Company Name: |
Absin Bioscience Inc.
|
| Tel: |
021-38015121 15000105423 |
| Email: |
wulan@absin.cn |
| Products Intro: |
Product Name:CA-224
CAS:883561-04-4
Purity:>98% Package:10mg;5mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CA224
CAS:883561-04-4
Purity:98% Package:100 mg；5 mg；50 mg
|
|
| Product Name: | CA-224 | | Synonyms: | CA-224;CA 224; CA224;[1,1'-Biphenyl]-4-carboxamide, N-[2-(1H-indol-3-yl)ethyl]-N-methyl- | | CAS: | 883561-04-4 | | MF: | C24H22N2O | | MW: | 354.44 | | EINECS: | | | Product Categories: | | | Mol File: | 883561-04-4.mol |  |
| | CA-224 Chemical Properties |
| Melting point | 178 °C | | Boiling point | 608.8±48.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | pka | 17.15±0.30(Predicted) | | form | Solid | | color | White to off-white |
| | CA-224 Usage And Synthesis |
| Description | CA-224 is potent CDK4 inhibitor, is also a nonplanar analogue of fascaplysin that specifically inhibits Cdk4-cyclin D1 in vitro. CA-224 blocks the growth of cancer cells at G0/ G1 phase of the cell cycle. CA-224 also blocks the cell cycle at G2/M phase, which is explained by the fact that it inhibits tubulin polymerization. Additionally, CA-224 acts as an enhancer of depolymerization for taxol-stabilized tubulin. CA-224 selectively induces apoptosis of SV40 large Tantigen. transformed cells and significantly reduces colony formation efficiency, in a dose-dependent manner, of lung cancer cells. The promising efficacy of CA-224 in human xenograft models as well as its excellent therapeutic window indicates its potential for clinical development. |
| | CA-224 Preparation Products And Raw materials |
|