SW-044248
中文名称 | SW-044248 |
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中文同义词 | 2-[(5-乙基-5H-1,2,4-三嗪并[5,6-B]吲哚-3-基)硫基]-N-(2-甲氧基苯基)丁酰胺;TOP1抑制剂(SW044248);化合物SW044248 |
英文名称 | 2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide |
英文同义词 | 2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide;SW-044248; 2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide;SW044248 >=98% (HPLC);Butanamide, 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-methoxyphenyl)-;SW-044248, >98%;CS-2302;SW 044248;SW044248 |
CAS号 | 522650-83-5 |
分子式 | C22H23N5O2S |
分子量 | 421.52 |
EINECS号 | |
相关类别 | 抑制剂;细胞生物学试剂 |
Mol文件 | 522650-83-5.mol |
结构式 | ![]() |
SW-044248 性质
储存条件 | 2-8°C |
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溶解度 | DMSO:10.5(最大浓度 mg/mL);24.91(最大浓度 mM) DMF:5.0(最大浓度 mg/mL);11.86(最大浓度 mM) 乙醇:1.0(最大浓度 mg/mL);2.37(最大浓度 mM) |
形态 | 粉末 |
颜色 | 白色至米色 |
Target | Value |
Topo1
() |
SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2, 5, 10 μM) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5, 10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21 CDKN1A . SW044248 is selectively toxic in 18/74 NSCLC lines.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-19637 | SW-044248 SW044248 | 522650-83-5 | 5mg | 900元 |
2024/04/30 | HY-19637 | SW-044248 SW044248 | 522650-83-5 | 10mM * 1mLin DMSO | 990元 |