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| Product Name: | MI-136 | | Synonyms: | MI-136;MI-136;HY-19319 (MI 136; MI136);;HY-19319 (MI 136;1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-;5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile;5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in;MI136;MI 136;CS-2162 | | CAS: | 1628316-74-4 | | MF: | C23H21F3N6S | | MW: | 470.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1628316-74-4.mol |  |
| | MI-136 Chemical Properties |
| Boiling point | 654.9±55.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 14.20±0.30(Predicted) | | color | White to off-white |
| | MI-136 Usage And Synthesis |
| Description | MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice. |
| | MI-136 Preparation Products And Raw materials |
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