- CP21R7
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- $100.00 / 1KG
-
2022-02-25
- CAS:125314-13-8
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
- CP21R7
-
- $100.00 / 1Kg/Bag
-
2022-02-25
- CAS:125314-13-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10kg
|
| | CP21R7(CP21) Basic information |
| Product Name: | CP21R7(CP21) | | Synonyms: | 3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione;CP21R7(CP21);CP21R7;3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;CS-2352;CP21 (CP21R7);3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)- | | CAS: | 125314-13-8 | | MF: | C19H15N3O2 | | MW: | 317.34 | | EINECS: | | | Product Categories: | | | Mol File: | 125314-13-8.mol |  |
| | CP21R7(CP21) Chemical Properties |
| Boiling point | 627.4±55.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | insoluble in EtOH; insoluble in H2O; ≥14.25 mg/mL in DMSO | | form | crystalline solid | | pka | 7.79±0.60(Predicted) | | color | Yellow to orange |
| | CP21R7(CP21) Usage And Synthesis |
| Uses | CP21R7 is a potent and selective inhibitor of GSK3β. | | Biological Activity | cp21r7 is a potent and selective inhibitor of gsk3β.the glycogen synthase kinase-3β (gsk-3β), a serine/threonine, is a ubiquitous kinase that participates in a multitude of cellular processes, such as cell membrane-to-nucleus signaling, gene transcription, translation, cytoskeletal structuring and cell cycle progression and survival [1]. | | in vitro | cp21r7 was an inhibitor of gsk3β and pkcα with the ic50 values of 1.8 and 1900 nm, respectively [1]. in the human reporter cell line, cp21r7 potently activated canonical wnt signallingeven at the dose of 1 μm, with highest activity seen at 3 μm [2]. in human ipscs exposed to n2b27 medium, supplemented with 1 μm gsk3β inhibitor cp21r7 strongly upregulated the expression of t (also known as brachyury, t/bry), a meso-endoderm marker expressed in the primitive streak [2]. | | references | [1] gong l, hirschfeld d, tan y c, et al. discovery of potent and bioavailable gsk-3β inhibitors[j]. bioorganic & medicinal chemistry letters, 2010, 20(5): 1693-1696.
[2] ciampi o, iacone r, longaretti l, et al. generation of functional podocytes from human induced pluripotent stem cells[j]. stem cell research, 2016, 17(1): 130-139. |
| | CP21R7(CP21) Preparation Products And Raw materials |
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