- EFT-508
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- $9.80 / 1.79999995231628KG
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2020-01-09
- CAS:1849590-01-7
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
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| | EFT-508 Basic information |
| Product Name: | EFT-508 | | Synonyms: | EFT-508;6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione;eFT508 -MNK;6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione;Tomivosertib eFT508;CS-2450;EFT 508;EFT-508;TOMIVOSERTIB;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione | | CAS: | 1849590-01-7 | | MF: | C17H20N6O2 | | MW: | 340.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1849590-01-7.mol |  |
| | EFT-508 Chemical Properties |
| Melting point | >300°C | | Boiling point | 735.6±60.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly, Heated), Methanol (Very Slightly) | | pka | 13.77±0.60(Predicted) | | form | Solid | | color | Pale Yellow |
| | EFT-508 Usage And Synthesis |
| Description | eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = <10 nM). It inhibits phosphorylation of eukaryotic initiation factor 4E (eIF4E) with an IC50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats. | | Uses | 6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione was used in the study of inhibitors of immune checkpoint modulators and related methods. eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor. |
| | EFT-508 Preparation Products And Raw materials |
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