| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:ML-291
CAS:1523437-16-2
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:ML-291
CAS:1523437-16-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:ML291
CAS:1523437-16-2
Purity:98% Package:5mg; 10mg; 25mg Remarks:Medbio
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:ML291 >=98% (HPLC)
CAS:1523437-16-2
Purity:NULL Package:25mg;5mg Remarks:NULL
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| Product Name: | ML291 | | Synonyms: | ML291;ML291 >=98% (HPLC);2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro- | | CAS: | 1523437-16-2 | | MF: | C16H16ClN3O6S | | MW: | 413.83 | | EINECS: | 808-922-2 | | Product Categories: | | | Mol File: | 1523437-16-2.mol |  |
| | ML291 Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤1mg/ml in DMSO;10mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 11.24±0.70(Predicted) | | color | Off-white to light yellow |
| | ML291 Usage And Synthesis |
| Biological Activity | ml-291 is an apoptosis inducer.apoptosis, a process of programmed cell death, occurs in multi-cellular organisms. biochemical events result in characteristic cell changes (morphology) and death. these changes include cell shrinkage, nuclear fragmentation, blebbing, chromatin condensation, chromosomal dna fragmentation, as well as global mrna decay. | | in vitro | ml-291 was identified as a novel activator of the apoptotic arm of the unfolded protein response (upr), but not the adaptive arm. specifically, ml-291 could activate signaling via perk/eif2α/chop with ec50 value of 762 nm but not through ire1/xbp1. moreover, ml-291 induced apoptosis in mouse embryonic fibroblasts overexpressing chop, but not in wild-type or chop knockout cells. ml-291 showed minimal activity against a panel of 67 receptors, ion channels, as well as transporters, with the exception of the dopamine transporter with 68% inhibition. in addition, ml-291 showed greater cytotoxicity than average antitumor cell cytotoxicity against colon, melanoma, and renal cancer cell lines in an nci-60 panel [1]. | | references | [1] flaherty, d. p.,golden, j.e.,liu, c., et al. selective small molecule activator of the apoptotic arm of the upr. probe reports from the nih molecular libraries program (2012). |
| | ML291 Preparation Products And Raw materials |
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