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BOC Sciences
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Product Name:Suprafenacine
CAS:1477482-50-0
Purity:99% Remarks:Suprafenacine is a destabilizer of microtubules (IC50 value 0.38 μM for microtubule polymerization inhibition) resulting in cell cycle arrest in the G2/M phase and apoptosis of cancer cells. Suprafena
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| Company Name: |
Jinan ponder chemical co. LTD
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0531-0000 |
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thinklifescience@163.com |
| Products Intro: |
Product Name:1477482-50-0
CAS:1477482-50-0
Purity:99% HPLC Package:1KG;500G;100G；50G;1G
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Suprafenacine manufacturers
- Suprafenacine
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- $58.00 / 1mg
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2024-10-25
- CAS:1477482-50-0
- Min. Order:
- Purity: 99.72%
- Supply Ability: 10g
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| | Suprafenacine Basic information |
| Product Name: | Suprafenacine | | Synonyms: | Suprafenacine;N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide;N-[(E)-(4-methylphenyl)methylideneamino]-4,5,6,7-tetrahydro-1~{H}-indazole-3-carboxamide;1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-, (2E)-2-[(4-methylphenyl)methylene]hydrazide;Suprafenacine >=98% (HPLC);7-tetrahydro-1H-indazole-3-carbohydrazide;N'-[(E)-(4-methylphenyl)methylidene]-4 | | CAS: | 1477482-50-0 | | MF: | C16H18N4O | | MW: | 282.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1477482-50-0.mol |  |
| | Suprafenacine Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 10 mg/ml | | form | A solid |
| | Suprafenacine Usage And Synthesis |
| Biological Activity | Suprafenacine is an inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activity.1 It inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM). Suprafenacine (10 μM) increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells. Suprafenacine (20 mg/kg) reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model. | | References | 1.Choi, B.-H., Chattopadhaya, S., Thanh, L.N., et al.Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilizationPLoS One9(10)e110955(2014) |
| | Suprafenacine Preparation Products And Raw materials |
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