| Company Name: |
Beijing HwrkChemical Technology Co., Ltd
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010-89508211 18501085097 |
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sales.bj@hwrkchemical.com |
| Products Intro: |
Product Name:(2R)-Octyl-α-hydroxyglutarate
CAS:1391194-67-4
Purity:97% Package:5g;25g;100g
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(2R)-Octyl-α-hydroxyglutarate manufacturers
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| | (2R)-Octyl-α-hydroxyglutarate Basic information |
| Product Name: | (2R)-Octyl-α-hydroxyglutarate | | Synonyms: | (2R)-Octyl-α-hydroxyglutarate;(R)-2-Hydroxy-pentanedioic acid 1-octyl ester;(2R)-2-Hydroxy-pentanedioic acid 1-octyl ester;(2R)-Octyl-.alpha.-hydroxyglutarate;(4R)-4-hydroxy-5-octoxy-5-oxopentanoic acid;Octyl-(R)-2HG;(2R)-Octyl-2-HG;Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2R)- | | CAS: | 1391194-67-4 | | MF: | C13H24O5 | | MW: | 260.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1391194-67-4.mol |  |
| | (2R)-Octyl-α-hydroxyglutarate Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 1 mg/ml | | form | powder | | color | white to beige |
| | (2R)-Octyl-α-hydroxyglutarate Usage And Synthesis |
| Uses | (2R)-Octyl-α-hydroxyglutarate is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research. | | Biological Activity | Octyl-(R)-2HG (Octyl-D-2HG) is a membrane-permeant precursor form of the oncometabolite D-2-hydroxyglutarate (D-2HG) produced by tumor cells due to mutations in the NADP+-dependent isocitrate dehydrogenase genes IDH1 and IDH2. D-2HG inhibits multiple α-ketoglutarate/α-KG-dependent dioxygenases by competing against α-KG binding. Cellular D-2HG delivery by Octyl-(R)-2HG treatment (1-50 mM) is shown to suppress demethylase activity (~148% H3K9me2 and ~310% H3K79me2 upregulation; 50 mM in U-87MG) as well as increase HIF-1α and decrease endostatin levels as a result of inhibiting α-KG-dependent dioxygenases prolyl hydroxylases (PHDs) and collagen prolyl-4-hydroxylase (C-P4H), respectively. |
| | (2R)-Octyl-α-hydroxyglutarate Preparation Products And Raw materials |
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