8-NITROTRYPTANTHRIN
| 中文名称 | 8-NITROTRYPTANTHRIN |
|---|---|
| 中文同义词 | 8-硝基吲哚并[2,1-B]喹唑啉-6,12-二酮;化合物GNF-PF-3777 |
| 英文名称 | 8-Nitrotryptanthrin |
| 英文同义词 | 8-Nitrotryptanthrin;GNF-PF-3777;Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-;GNF-PF-3777 (8-Nitrotryptanthrin);GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO);8-Nitroindolo[2,1-b]quinazoline-6,12-dione |
| CAS号 | 77603-42-0 |
| 分子式 | C15H7N3O4 |
| 分子量 | 293.23 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 77603-42-0.mol |
| 结构式 |  |
8-NITROTRYPTANTHRIN 性质
| 熔点 | >250 °C |
|---|---|
| 沸点 | 551.2±52.0 °C(Predicted) |
| 密度 | 1.67±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO：4.2（最大浓度 mg/mL）；14.32（最大浓度 mM） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | -7.55±0.20(Predicted) |
| 颜色 | 白色至米白色 |
|
rhIDO2 1.8 μM (IC 50 ) |
rhIDO2 0.97 μM (Ki) |
The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC 50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC 50 of 0.82 μM. GNF-PF-3777 (8-Nitrotryptanthrin) has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 5mg | 2500元 |
| 2024/04/30 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 10mg | 3800元 |