| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CP-392,110 maleate
CAS:199656-46-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:CP-465022 (maleate)
CAS:199656-46-7
Purity:98% Package:5mg; 10mg Remarks:Medbio
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CP-465022 (maleate)
CAS:199656-46-7
Purity:98% Package:1 mg；2 mg；5 mg
|
|
| | CP-465022 (maleate) Basic information |
| Product Name: | CP-465022 (maleate) | | Synonyms: | CP-465022 (maleate);CP-465022 Maleate, 3-(2-Chlorophenyl)-2-[2-[6- [(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro- 4(3H)-quinazolinone Maleate;CP-392,110 (maleate);WLLUWLRVXIHECY-KSUUAYPFSA-N;3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone-(2Z)-2-butenedioate | | CAS: | 199656-46-7 | | MF: | C30H28ClFN4O5 | | MW: | 579.03 | | EINECS: | | | Product Categories: | | | Mol File: | 199656-46-7.mol |  |
| | CP-465022 (maleate) Chemical Properties |
| storage temp. | Room temperature | | solubility | Soluble in DMSO | | form | A crystalline solid |
| | CP-465022 (maleate) Usage And Synthesis |
| Biological Activity | cp-465022 is an ampa antagonist.the inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor has been hypothesized to lead to neuroprotective efficacy after cerebral ischemia on the basis of the activity in ischemia models of a variety of compounds with varying selectivity for ampa over other glutamate receptor subtypes. | | in vitro | cp-465022 inhibited ampa receptor-mediated currents in rat cortical neurons and such inhibition was found to be noncompetitive with agonist concentration. cp-465022 was selective for ampa over kainate and n-methyl-d-aspartate receptors. however, cp-465022 was found to be equipotent for ampa receptors composed of different ampa receptor subunit combinations, which indicated that cp-465022 is equivalently potent for inhibition of ampa receptor-mediated responses in different types of neurons expressing different ampa receptor subunits [1]. | | in vivo | animal study showed that cp-465022 could potently and efficaciously inhibit ampa receptor-mediated hippocampal synaptic transmission and the induction of seizures. however, at comparable doses, cp-465022 failed to prevent ca1 neuron loss after brief global ischemia or to reduce infarct volume after temporary middle cerebral artery occlusion [2]. | | IC 50 | 25 nm for ampa receptor-mediated currents in rat cortical neurons | | references | [1] lazzaro jt, paternain av, lerma j, chenard bl, ewing fe, huang j, welch wm, ganong ah, menniti fs. functional characterization of cp-465,022, a selective, noncompetitive ampa receptor antagonist. neuropharmacology. 2002 feb;42(2):143-53.
[2] menniti fs, buchan am, chenard bl, critchett dj, ganong ah, guanowsky v, seymour pa, welch wm. cp-465,022, a selective noncompetitive ampa receptor antagonist, blocks ampa receptors but is not neuroprotective in vivo. stroke. 2003 jan;34(1):171-6. |
| | CP-465022 (maleate) Preparation Products And Raw materials |
|