6-甲基-2-[(4-甲基苯基)氨基]-4H-3,1-苯并嗪-4-酮 基本信息
| 中文名称 | 6-甲基-2-[(4-甲基苯基)氨基]-4H-3,1-苯并嗪-4-酮 |
|---|---|
| 中文同义词 | 6-甲基-2-对甲苯基氨基-4H-3,1-苯并恶嗪-4-酮;6-甲基-2-[(4-甲基苯基)氨基]-4H-3,1-苯并嗪-4-酮;6-甲基-2-对甲苯基氨基-4H-3,1-苯并恶嗪-4-酮;6-甲基-2-[(4-甲基苯基)氨基]-4H-3,1-苯并噁嗪-4-酮;6-甲基-2-[(4-甲基苯基)氨基]-4H-3,1-苯并恶嗪-4-酮 |
| 英文名称 | URB754 |
| 英文同义词 | URB754;6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one;6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one;6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one;6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one;URB754, >=98% |
| CAS号 | 86672-58-4 |
| 分子式 | C16H14N2O2 |
| 分子量 | 266.3 |
| EINECS号 | |
| 相关类别 | 其它杂环;Aromatics;Heterocycles;Research Chemical;URB754 is a potent, noncompetitive inhibitor of MGL.;All Inhibitors;Inhibitors;Chemical for Research |
| Mol文件 | 86672-58-4.mol |
| 结构式 | ![6-甲基-2-[(4-甲基苯基)氨基]-4H-3,1-苯并嗪-4-酮 结构式](CAS/GIF/86672-58-4.gif) |
6-甲基-2-[(4-甲基苯基)氨基]-4H-3,1-苯并嗪-4-酮 性质
| 熔点 | 238-240°C |
|---|---|
| 沸点 | 434.0±48.0 °C(Predicted) |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（轻微、加热） |
| 酸度系数(pKa) | 3.76±0.20(Predicted) |
| 形态 | 灰白色固体。 |
| 颜色 | 白色至类白色 |
用途
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with a n IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
安全信息
| 海关编码 | 2934.99.4400 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | M2572 | 6-甲基-2-对甲苯基氨基-4H-3,1-苯并恶嗪-4-酮 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one | 86672-58-4 | 10mg | 260元 |
| 2024/04/30 | M2572 | 6-甲基-2-对甲苯基氨基-4H-3,1-苯并恶嗪-4-酮 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one | 86672-58-4 | 50mg | 870元 |