Isosteviol ((-)-Isosteviol) 是一种甜菊糖苷衍生物，是甜菊糖苷通过酸催化水解产生的。Isosteviol 抑制 DNA 聚合酶和 DNA 拓扑异构酶，并具有抗菌，抗癌和抗结核作用。
Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10
-8
M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10
-2
M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10
-8
M vasopressin.
The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca
2+
]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca
2+
]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present.
Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.
化学性质
白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甜菊（Stevia rebaudiana Bertoni）又名甜叶菊、甜草。
用途
异甜菊醇具有抗高血压、降低血糖、抑制癌细胞的作用。
用途
用于含量测定/鉴定/药理实验等
