GLABRESCIONE B
| 中文名称 | GLABRESCIONE B |
|---|---|
| 中文同义词 | |
| 英文名称 | Glabrescione B |
| 英文同义词 | Glabrescione B;Glabrescione B (GlaB);3-[3,4-bis-(3-methyl-but-2-enyloxy)-phenyl]-5,7-dimethoxy-chromen-4-one;GlaB;4H-1-Benzopyran-4-one, 3-[3,4-bis[(3-methyl-2-buten-1-yl)oxy]phenyl]-5,7-dimethoxy- |
| CAS号 | 65893-94-9 |
| 分子式 | C27H30O6 |
| 分子量 | 450.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 65893-94-9.mol |
| 结构式 |  |
GLABRESCIONE B 性质
| 沸点 | 608.0±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.142±0.06 g/cm3(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Glabrescione B 是第一个结合 Hedgehog (Hh) 调节剂 Gli1 并通过干扰 Gli1-DNA 相互作用而削弱其活性的化合物。Glabrescione B 抑制 Hedgehog 依赖性肿瘤细胞的生长，抑制肿瘤源性干细胞的自我更新能力和克隆能力。
Gli1-DNA Interaction
Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma.
Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels.
Cell Proliferation Assay
| Cell Line: | ASZ001 BCC cells |
| Concentration: | 5 μM |
| Incubation Time: | 24-72 hours |
| Result: | Basal cell carcinoma cell proliferation was impaired. |
Western Blot Analysis
| Cell Line: | ASZ001 BCC cells |
| Concentration: | 1-10 μM |
| Incubation Time: | 24-48 hours |
| Result: | Gli1 mRNA expression levels was decreased. |
| Animal Model: | Female NOD/SCID mice (ASZ001 BCC allografts) |
| Dosage: | 100 μmol/kg |
| Administration: | I.p.; every second day for 18 days |
| Result: | A significant reduction of tumor growth as well as Gli1 mRNA levels was observed. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-122590 | Glabrescione B | 1 mg | 2045元 | |
| 2024/04/30 | HY-122590 | Glabrescione B | 65893-94-9 | 5mg | 4500元 |