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GSK172981

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GSK172981 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:GSK172981；GSK-172981;GSK 172981
CAS:1133705-99-3
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:GSK172981
CAS:1133705-99-3
GSK172981 Basic information
Product Name:GSK172981
Synonyms:GSK172981;4-Quinolinecarboxamide, 3-amino-N-[(S)-cyclopropylphenylmethyl]-2-(3-fluorophenyl)-
CAS:1133705-99-3
MF:C26H22FN3O
MW:411.47
EINECS:
Product Categories:
Mol File:1133705-99-3.mol
GSK172981 Structure
GSK172981 Chemical Properties
Boiling point 603.9±55.0 °C(Predicted)
density 1.301±0.06 g/cm3(Predicted)
pka12.34±0.46(Predicted)
Safety Information
MSDS Information
GSK172981 Usage And Synthesis
DescriptionGSK172981 is a non-peptide tachykinin NK3 receptor antagonist. GSK172981 demonstrated high affinity for recombinant human (pK(i) value 7.7) and native guinea pig (pK(i) value 7.8) tachykinin NK(3) receptors. In vitro functional evaluations revealed GSK172981 to be a competitive antagonist (pA(2)=7.2) at cloned human tachykinin NK(3) receptor. GSK172981 also exhibited a competitive profile in antagonizing neurokinin B-stimulated neuronal activity recorded from the guinea pig medial habenula slices (apparent pK(B)=8.1). GSK172981 is potentially useful in the treatment of schizophrenia.
GSK172981 Preparation Products And Raw materials
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