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| | PF-06471553 Basic information |
| Product Name: | PF-06471553 | | Synonyms: | PF-06471553;PF 06471553,PF06471553;1H-Isoindole-5-sulfonamide, N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2,3-dihydro-2-[2-(3-methoxyphenyl)acetyl]- | | CAS: | 1808094-07-6 | | MF: | C23H25N5O4S | | MW: | 467.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1808094-07-6.mol |  |
| | PF-06471553 Chemical Properties |
| Boiling point | 728.7±70.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 150 mg/mL (320.83 mM) | | form | Solid | | pka | 6.75±0.20(Predicted) | | color | White to off-white |
| | PF-06471553 Usage And Synthesis |
| Description | PF-06471553 is a potent and selective Monoacylglycerol acyltransferase 3 (MGAT3) inhibitor. PF-06471553 selectively inhibits MGAT3 with high in vitro potency and cell efficacy. In the presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2) inhibitors, an oral administration of PF-06471553 exhibited inhibition of the incorporation of deuterium-labeled glycerol into TAG in mouse model. Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis. |
| | PF-06471553 Preparation Products And Raw materials |
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