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| | AX-024 hydrochloride Basic information |
| Product Name: | AX-024 hydrochloride | | Synonyms: | AX-024;AX024;AX 024;AX-024 hydrochloride;AX-024;1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride;AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor | | CAS: | 1704801-24-0 | | MF: | C21H23ClFNO2 | | MW: | 375.87 | | EINECS: | | | Product Categories: | | | Mol File: | 1704801-24-0.mol |  |
| | AX-024 hydrochloride Chemical Properties |
| storage temp. | -20° | | solubility | Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming). | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| | AX-024 hydrochloride Usage And Synthesis |
| Description | AX-024 is an inhibitor of the CD3ε-Nck interaction. It binds to the SH3.1 N-terminal domain of Nck1, preventing its binding to the proline-rich sequence of the CD3ε subunit of T cells. AX-024 inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM for human T cells) and selectively decreases proliferation of T cells over B cells. It prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 10 mg/kg per day for ten days starting on the day of immunization. AX-024 (50 mg/kg) prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway, as well as prevents an increase in IL-4 levels in bronchoalveolar lavage fluid (BALF), in an ovalbumin-sensitized mouse model of allergic airway disease. It does not prevent the memory T cell response to an immunodominant B8R poxvirus antigen peptide or to infection by ectromelia virus (mousepox). | | Uses | AX-024 is a T cell receptor inhibitor for the treatment of autoimmune diseases. | | References | 1) Borroto et al. (2016), First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases; Sci. Transl. Med., 8 370ra184 |
| | AX-024 hydrochloride Preparation Products And Raw materials |
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