| Company Name: |
Borenpharm Co., Ltd
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| Tel: |
027-65563561 |
| Email: |
sales@borenpharm.com |
| Products Intro: |
Product Name:ETHYL 2-(2-(2-(2-HYDROXYETHOXY)ETHOXY)ETHOXY)-ACETATE
CAS:118988-04-8
Purity:95% HPLC Package:1g; 5g Remarks:1.82g
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| Company Name: |
Amatek Scientific Co. Ltd.
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| Tel: |
0512-56316828 |
| Email: |
info@amateksci.com |
| Products Intro: |
Product Name:HO-PEG3-CH2COOEt
CAS:118988-04-8
Purity:97% HPLC Package:1g;5g;25g;100g
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| Company Name: |
Shanghai Tube Pharmaceutical Co., Ltd.
|
| Tel: |
021-54338626 18017892860 |
| Email: |
sales@tubepharm.com |
| Products Intro: |
Product Name:ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate
CAS:118988-04-8
Purity:95% Package:5g,10g,100g,1kg
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| | ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Basic information |
| Product Name: | ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate | | Synonyms: | HO-PEG3-CH2COOEt;ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate;Hydroxy-PEG3-ethyl acetate;HO-PEG3-CH2COOEt/Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, ethyl ester;Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, ethyl ester | | CAS: | 118988-04-8 | | MF: | C10H20O6 | | MW: | 236.26 | | EINECS: | | | Product Categories: | | | Mol File: | 118988-04-8.mol |  |
| | ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Chemical Properties |
| Boiling point | 332.3±27.0 °C(Predicted) | | density | 1.105±0.06 g/cm3(Predicted) | | pka | 14.36±0.10(Predicted) |
| | ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Usage And Synthesis |
| Biological Activity | Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Preparation Products And Raw materials |
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