| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:90% (HPLC) Remarks:recombinant, expressed in baculovirus infected insect cells, ≥50% (SDS-PAGE)
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| Company Name: |
Alexis Corporation
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| Tel: |
+41 61 926 8989 |
| Email: |
alexis-ch@alexis-corp.ch |
| Products Intro: |
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| Company Name: |
VWR International
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| Tel: |
800 932 5000 |
| Email: |
solutions@vwr.com |
| Products Intro: |
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| Product Name: | HD2 | | Synonyms: | HISTONE DEACETYLASE;HISTONE DEACETYLASE HD2;HISTONE DEACETYLASE (RAT);HISTONE DEACETYLASE, RAT LIVER;HDAC;HDAC (RAT);HD2;Anti-HDAC2, C-Terminal antibody produced in rabbit | | CAS: | 9076-57-7 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HD2 Structure]() |
| Fp | 87 °C | | storage temp. | -70°C | | form | aqueous solution | | biological source | human |
| Uses | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. | | Biological Activity | Histone deacetylase 2 (HDAC2) is known to regulate DNA damage signalling, maintain genomic stability and prevents tumor formation and progression. Hdac2 does not possess a DNA binding domain, it forms multi-component repressor complexes for its interaction with transcription factors. Hdac2 also mediates cell proliferation, differentiation and apoptosis. HDAC2 controls response to chronic inflammation in COPD (chronic obstructive pulmonary disease). It activates Wnt signaling pathway via β-catenin T-cell transcription factor. Deletion of HDAC2 along with HDAC1 leads to anemia and thrombocytopenia. |
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