CS-2628
| 中文名称 | CS-2628 |
|---|---|
| 中文同义词 | MMP/TACE和ADAM抑制剂(TAPI-2);化合物TAPI-2;N1-((S)-1-(((S)-1-((2-氨基乙基)氨基)-1-氧代丙-2-基)氨基)-3,3-二甲基-1-氧代丁-2-基)-N4-羟基-2-异丁基丁二酰胺 |
| 英文名称 | TAPI-2 |
| 英文同义词 | TAPI-2;N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE;N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE;TNF-ALPHA PROTEASE INHIBITOR-2;HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2;N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide;N-[2-[2-(HydroxyaMino)-2-oxoethyl]-4-Methyl-1-oxopentyl]-3-Methyl-L-valyl-N-(2-aMinoethyl)-L-alaninaMide Acetic Acid;CS-2628 |
| CAS号 | 187034-31-7 |
| 分子式 | C19H37N5O5 |
| 分子量 | 415.53 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;A hydroxamate-based inhibitor of MMPs and TACE. |
| Mol文件 | Mol File |
| 结构式 |  |
CS-2628 性质
| 密度 | 1.127±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 乙醇：5mg/mL；水：8mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.17±0.20(Predicted) |
| 颜色 | 白色至米白色 |
| 敏感性 | Light Sensitive & Hygroscopic |
|
MMP 20 μM (IC 50 ) |
The hydroxamate-based metalloprotease inhibitor TAPI-2 bounds to hmeprin with inhibition constants IC 50 20±10 μM for hmeprin β subunit and 1.5±0.27 nM for hmeprin α subunit. Generally, hmeprin α is inhibited more strongly than the β subunit. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of NICD and HES-1 confirm that the concentration used (20 μM) is within the effective dose range of TAPI-2 (5-40 μM).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-100211 | CS-2628 TAPI-2 | 187034-31-7 | 1mg | 1700元 |
| 2024/08/19 | HY-100211 | CS-2628 TAPI-2 | 187034-31-7 | 5mg | 6000元 |