| Company Name: |
Dalian Meilun Biotech Co., Ltd.
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| Tel: |
0411-62910999 13889544652 |
| Email: |
sales@meilune.com |
| Products Intro: |
Product Name:CAY-10410
CAS:596104-94-8
Purity:>98%,BR Package:1MG Remarks:MB6151
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10410
CAS:596104-94-8
Purity:98% (isomer mixture) Package:1G;10G;100G Remarks:CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. It was designed as an analo
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| | 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Basic information |
| Product Name: | 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID | | Synonyms: | 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID;9,10-DIHYDRO-15-DEOXY-DELTA12,14-PROSTAGLANDIN J2;CAY10410;9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2;AFBJLDUEEOOVHL-WKELIDJCSA-N;Prosta-5,12,14-trien-1-oic acid, 11-oxo-, (5Z,12E,14Z)-;CAY10410,CAY-10410 | | CAS: | 596104-94-8 | | MF: | C20H30O3 | | MW: | 318.45 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 100 mg/ml; DMSO: 20 mg/ml; Ethanol: 75 mg/ml; PBS (7.2): 2.7 mg/ml |
| | 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Usage And Synthesis |
| Description | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ.1 Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.2 CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM.3 | | References | 1. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 83(5),803-812(1995).
2. Atsmon, J., Sweetman, B.J., Baertschi, S.W., et al. Formation of thiol conjugates of 9-deoxy-Δ9,Δ12(E)-prostaglandin D2 and Δ12(E)-prostaglandin D2 Biochemistry 29,3760-3765(1990).
3. Shibata, T., Yamada, T., Ishii, T., et al. Thioredoxin as a molecular target of cyclopentenone prostaglandins J. Biol. Chem. 278(28),26046-26054(2003). |
| | 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Preparation Products And Raw materials |
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