| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse
Purity:~1 mg/mL, clone K58/35, purified immunoglobulin Package:.1MG Remarks:S8809-.1MG
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| | ANTI-PAN NAV Basic information |
| | ANTI-PAN NAV Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | biological source | rabbit |
| | ANTI-PAN NAV Usage And Synthesis |
| Uses | Anti-Sodium Channel, Pan antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), immunoprecipitation and chemiluminescent western blot. | | General Description | Voltage-gated sodium channels (VGSC) are membrane proteins that are usually present in excitable cells. These sodium channels regulate neurological functions such as the generation of action potentials in nerve cells. Alterations in neurological sodium ion channels have been associated with epilepsy, whereas mutations in cardiac sodium channels have been linked to long QT syndrome . Anti-Sodium Channel, Pan antibody is specific for the α subunit of VGSC in rats. | | Biological Activity | Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders. |
| | ANTI-PAN NAV Preparation Products And Raw materials |
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