ARG-PRO-PRO-GLY-PHE
中文名称 | ARG-PRO-PRO-GLY-PHE |
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中文同义词 | 1-5-血管舒缓激肽;2-[[2-[[1-[1-[2-AMINO-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]PYRROLIDINE-2-CARBONYL]PYRROLIDINE-2-CARBONYL]AMINO]ACETYL]AMINO]-3-PHENYLPROPANOIC ACID;(S)-2-(2-((S)-1-((S)-1-((S)-2-氨基-5-胍基戊酰基)吡咯烷-2-羰基)吡咯烷-2-甲酰胺)乙酰胺)-3-苯基丙酸;血管舒缓激肽(BK) 片段 (1-5);缓激肽1-5;缓激肽片段 1-5;缓激肽BRADYKININ(1-5) |
英文名称 | H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT |
英文同义词 | RPPGF;ARG-PRO-PRO-GLY-PHE;ARG-PRO-PRO-GLY-PHE ACETATE;BRADYKININ (1-5);BRADYKININ FRAGMENT 1-5;H-ARG-PRO-PRO-GLY-PHE-OH TFA;H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT;H-Arg-Pro-Pro-Gly-Phe-OH |
CAS号 | 23815-89-6 |
分子式 | C27H40N8O6 |
分子量 | 572.66 |
EINECS号 | |
相关类别 | 细胞信号和神经生物学;细胞生物学;Peptide |
Mol文件 | 23815-89-6.mol |
结构式 |
ARG-PRO-PRO-GLY-PHE 性质
密度 | 1.46±0.1 g/cm3(Predicted) |
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储存条件 | -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 3.50±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED 50 of 183±2 pmol/min.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-P1488 | ARG-PRO-PRO-GLY-PHE Bradykinin (1-5) | 23815-89-6 | 1mg | 550元 |
2024/08/19 | HY-P1488 | ARG-PRO-PRO-GLY-PHE Bradykinin (1-5) | 23815-89-6 | 5mg | 1800元 |