LDN-91946
| 中文名称 | LDN-91946 |
|---|---|
| 中文同义词 | 化合物 T15729;化合物LDN-91946;3-氨基-2-苯甲酰基-6-氧代-6,7-二氢噻吩并[2,3-B]吡啶-5-羧酸 |
| 英文名称 | 3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid |
| 英文同义词 | 3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid;Thieno[2,3-b]pyridine-5-carboxylic acid, 3-amino-2-benzoyl-6,7-dihydro-6-oxo-;LDN-91946,Inhibitor,Ubiquitin,LDN 91946,inhibit,Deubiquitinase,UCH-L1,DUBs,selective,LDN91946;3-Amino-2-benzoyl-6-oxo-6H,7H-thieno[2,3-b]pyridine-5-carboxylic acid |
| CAS号 | 439946-22-2 |
| 分子式 | C15H10N2O4S |
| 分子量 | 314.3159 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 439946-22-2.mol |
| 结构式 |  |
LDN-91946 性质
| 熔点 | 327-329 °C(Solv: acetic acid (64-19-7)) |
|---|---|
| 沸点 | 714.0±60.0 °C(Predicted) |
| 密度 | 1.554±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：83.33 mg/mL（265.11 mM） |
| 酸度系数(pKa) | 2.26±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅棕色至棕色 |
LDN-91946 是一种有效的非竞争性的选择性泛素羧基末端水解酶-L1 (UCH-L1) 抑制剂，Ki app 为 2.8 μM.
Ki app: 2.8 μM (UCH-L1)
LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM.
There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM.