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ANTI-U2 AUXILIARY FACTOR

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ANTI-U2 AUXILIARY FACTOR Suppliers list
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:Monoclonal Anti-U2AF65
Purity:monoclonal MC3, purified from hybridoma cell culture Package:200μL Remarks:U4758
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
Email:
Products Intro: Purity:clone MC3, purified from hybridoma cell culture Remarks:Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Company Name: SIGMA-RBI  
Tel: 800 736 3690 (Orders)
Email:
Products Intro:
Company Name: Zymed Laboratories Inc.  
Tel: 800 874 4494 (Customer Service)
Email:
Products Intro:
ANTI-U2 AUXILIARY FACTOR Basic information
Product Name:ANTI-U2 AUXILIARY FACTOR
Synonyms:MONOCLONAL ANTI-U2AF65;ANTI-U2AF65;ANTI-U2 AUXILIARY FACTOR;Monoclonal Anti-U2AF65 antibody produced in mouse
CAS:
MF:
MW:0
EINECS:
Product Categories:Antibodies to Splicing FactorsCell Biology;Alphabetical Index;Antibodies for Gene Regulation and Expression;Antibodies for RNA Regulation and Translation;Antibodies to Transcription RegulatorsAntibodies;Clone Index;MAntibodies;U
Mol File:Mol File
ANTI-U2 AUXILIARY FACTOR Structure
ANTI-U2 AUXILIARY FACTOR Chemical Properties
storage temp. -20°C
form buffered aqueous solution
Safety Information
WGK Germany -
MSDS Information
ProviderLanguage
SigmaAldrich English
ANTI-U2 AUXILIARY FACTOR Usage And Synthesis
UsesMonoclonal Anti-U2AF65 antibody produced in mouse has been used in:
  • RNA immunoprecipitation
  • immunoblotting
  • chromatin immunoprecipitation (ChIP)
  • enzyme-linked immunosorbent assay (ELISA)
  • immunohistochemistry
  • immunocytochemistry
  • immunoelectron microscopy

General DescriptionMonoclonal Anti-U2AF65 (mouse IgG2b isotype) is derived from the MC3 hybridoma produced by the fusion of mouse myeloma cells (Ag8.653 cells) and splenocytes from BALB/c mice immunized with recombinant human U2AF65. U1, U2, U4/U6, and U5 are small nuclear riboprotein (snRNPs) that are major subunits of spliceosomes. Spliceosomes also contain non snRNPs proteins such as alternative splicing factor/splicing factor 2 (ASF/SF2), 35 kDa spliceosomal component (SC-35) and U2 snRNP auxiliary splicing factor (U2AF). U2 snRNP auxiliary factor 65 kDa (U2AF65) is a splicing factor which has three C-terminal RNA recognition motifs (RRMs) and an N-terminal arginine/serine-rich (RS) domain. This gene is mapped to human chromosome 19q13.42. Splicing factor U2AF65kDa subunit is a non-snRNP protein component of spliceosome complexes.
Biochem/physiol ActionsU2 snRNP auxiliary factor 65 kDa (U2AF65)/U2AF2 helps to supply the small nuclear ribonucleoprotein (snRNP) U2, which is subunit of the spliceosome. It can induce the exclusion of alternative exons. U2AF65 primarily regulates the splicing of pre-mRNA. The serine-rich (RS) repeats at the N-terminal region act as a signalling factor for nuclear localization. (U2AF65) and (U2AF35) are components of the splicing factor U2AF that transports between the cytoplasm and the nucleus.
ANTI-U2 AUXILIARY FACTOR Preparation Products And Raw materials
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